The IMPDH2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to IMPDH2. This antibody recognizes Human, Mouse, and Rat antigen. The IMPDH2 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Description: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy-and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Function: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Subunit Structure: Homotetramer (PubMed:7903306, Ref. 24, Ref. 25). Interacts with CLOCK; in a circadian manner (PubMed:28985504).
Post-translational Modifications: The N-terminus is blocked. Acetylated by CLOCK in a circadian manner (PubMed:28985504).
Similarity: Belongs to the IMPDH/GMPR family